A number of studies have pointed to CBG’s efficacy against colorectal cancer via TRPM8 antagonism including a 2014 paper published in Carcinogenesis which described potent in vivo action that promoted apoptosis (programmed cell death), improved oxidative stress responses, and reduced cell growth in colorectal cancer cells.
The therapeutic potential of cannabinoid synergy, known as the Entourage or Ensemble Effect, was also discussed in a 2018 study that examined activity against breast cancer cell lines. Referencing extensive preclinical data that demonstrated cannabinoids can trigger antitumor responses in various forms of cancer,
In pre-clinical work that looked at human stomach and bone cancer cell lines in vitro, CBG was found to be more effective than its acidic form, CBGA, against diseased cells. Additionally, investigators demonstrated the potency of both CBG and CBC (cannabichromene) against gastrointestinal cancer cells. Here, both cannabinoids were shown to induce significantly higher rates of cancer cell death compared to other cannabinoids and suggest the need for further investigation into synergistic efficacy.
The potential of CBG to regulate inflammatory and oxidative mechanisms across numerous receptor sites bodes well for its use against a plethora of pathologies. In fact, in a GW Pharmaceuticals patent application, the company provided a large list of diseases and conditions where they felt CBG research was warranted:
"...pain (including but not limited to acute pain; chronic pain; neuropathic pain and cancer pain), neurodegenerative disease (including but not limited to Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; Huntington's disease; multiple sclerosis; frontotemporal dementia; prion disease; Lewy body dementia; progressive supranuclear palsy; vascular dementia; normal pressure hydrocephalus; traumatic spinal cord injury; HIV dementia; alcohol induced neurotoxicity; Down's syndrome; epilepsy or any other related neurological or psychiatric neurodegenerative disease), ischemic disease (including but not limited to stroke; cardiac ischemia; coronary artery disease; thromboembolism; myocardial infarction or any other ischemic related disease), brain injury or damage (including but not limited to traumatic brain injury is taken from the group: diffuse axonal injury; concussion; contusion; whiplash or any other traumatic head or brain injury), acquired brain injury (including but not limited to stroke; anoxic brain injury; hypoxic brain injury or any other acquired brain injury), age related inflammatory or autoimmune disease, cachexia (including related conditions such as AIDS wasting disease, weight loss associated with cancer, chronic obstructive pulmonary disease or infectious diseases such as tuberculosis), nausea and vomiting, glaucoma, movement disorders, rheumatoid arthritis, asthma, allergy, psoriasis, Crohn's disease, systemic lupus erythematosus, diabetes, cancer, osteoporosis, renal ischemia and nephritis."